Antithymocyte globulin and transplants for aplastic anemia.

have completed a study on the use of antithymocyte globulin (ATG) as part of the conditioning regimen for severe aplastic anemia (SAA) patients, undergoing an allogeneic stem cell transplant (HSCT) from matched sibling (MSD) or unrelated (UD) donors. The Authors have found that rabbit ATG (thymoglobulin, Sanofi, France), as compared to horse ATG (ATGAM, Pfizer, USA) is associated with less acute graft-versus-host disease (GvHD), less chronic GvHD in MSD grafts, and improved survival in UD grafts, and recommend the use of rabbit ATG in the conditioning regimen for patients with SAA. The hypothesis for improved outcome of patients receiving rabbit ATG is that rabbit ATG is associated with more effective depletion of lymphocytes, and that rabbit ATG, but not horse ATG, enhances the number and function of regulatory T cells, which may be relevant in controlling GvHD and inducing tolerance. Horse ATG was part of the original protocol designed by Storb et al. for transplants from human leukocyte antigen (HLA)-identical siblings in SAA, together with cyclophosphamide (CY) 200 mg/kg. This protocol (CY200-ATG), followed by the infusion of unmanipulated bone marrow (BM) cells, was introduced more than 4 decades ago and is still considered the standard of care for young patients grafted from MSDs, with survival exceeding 80% for these patients. However, several questions remain open, the first being whether we should continue to use ATG in 2017, especially as a prospective trial in 134 SAA patients failed to show a benefit for patients randomized to the horse ATG arm. The study by Kekre and et al. focused solely on patients receiving ATG, and thus we are missing the control arm. A registry-based study on HLAidentical sibling transplants (n=1886) showed a significant survival advantage for patients receiving ATG , irrespective of whether this was derived from horse or rabbit, both in univariate and multivariate analysis. Therefore the answer to this first question is that ATG should be part of the conditioning regimen for SAA grafted from identical siblings, and the study by Kekre and colleagues suggests Editorials